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US 12,522,554 B2Granted
Method for preparing intermediate for synthesis of sphingosine-1-phosphate receptor agonist
AssigneeLG Chem, Ltd.
InventorsSung Wook Kim, Ki Dae Kim, Soo Min Lee, Ho Yeon Lee, Jin Ok Ham
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Abstract
The present invention relates to a novel method for producing an intermediate expressed by chemical formula 5 that can be effectively used in synthesis of sphingosine-1-phosphate receptor agonist.
Claims11
A method for preparing an intermediate compound of the following Formula 5 comprising the following steps of:
- i) a step of preparing a compound of Formula 3 by reacting a compound of Formula 2 with an acetylating agent and a base in an organic solvent,
- ii) a step of preparing a compound of Formula 4 by Vilsmeier-Haack reaction of the compound of Formula 3, and
- iii) a step of preparing the intermediate compound of Formula 5 by removing an acetyl group from the compound of Formula 4:
- wherein,
- R1 and R2 are each independently hydrogen, alkyl, halogen, haloalkyl or alkoxyalkyl.
2 more elements
Dependencies are inferred from the claim text.