Architectures for production of nitric oxide

A nitric oxide (NO) generation system, comprising:

• one or more plasma chambers configured to ionize a reactant gas to generate a plasma for producing a product gas containing nitric oxide (NO) using a flow of the reactant gas through the one or more plasma chambers;
• a controller configured to regulate an amount of nitric oxide in the product gas using one or more parameters as an input to the controller, the one or more parameters including information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and an inspiratory gas into which the product gas flows;
• and
• a flow divider configured to divide a flow of the product gas from the one or more plasma chambers into a first gas flow to provide a flow to the inspiratory gas and a second gas flow to be released into an environment as excess product gas,
• wherein the controller is configured to determine an amount of product gas to deliver to the first gas flow such that the first gas flow is in direct proportion to a flow rate of the inspiratory gas, and a flow rate of the second gas flow is a difference between a product gas flow rate from the one or more plasma chambers and a flow rate of the first gas flow.