Method and apparatus for oncomagnetic treatment
AssigneeThe Methodist Hospital
InventorsSantosh Anand Helekar, David Stuart Baskin, Martyn Alun Sharpe, Kumar Pichumani
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Abstract
To disrupt mitochondrial function in certain cells, controlling hardware causes a magnet to oscillate so as to generate an oscillating magnetic field. The oscillating magnetic field is applied to a volume of tissue including cells with degraded mitochondria to trigger apoptosis in the cells with degraded mitochondria.
Claims20
A method for disrupting mitochondrial function or inducing apoptosis or cell death in cancer cells, the method comprising:
- causing, by controlling hardware, one or more magnets along (i) a first axis and a (ii) a second axis substantially orthogonal to the first axis to oscillate so as to generate an oscillating magnetic field;
- and
- applying the oscillating magnetic field to a tissue comprising cancer cells, including:
- ramping up a frequency of the oscillating magnetic field to a peak frequency of 50-350 Hz, and
- generating a series of stimulus pulses of a first duration separated by inter-stimulus pulse intervals of a second duration, wherein the first duration is in a range of 10 milliseconds to 5 seconds, and the second duration is in a range of 10 milliseconds to 10 minutes.
A device for disrupting mitochondrial function or inducing apoptosis or cell death in cancer cells, the device comprising:
- one or more magnets;
- and
- controlling hardware configured to:
- cause the one or more magnets along (i) a first axis and a (ii) a second axis substantially orthogonal to the first axis to oscillate so as to generate an oscillating magnetic field,
- ramp up a frequency of the oscillating magnetic field to a peak frequency of 50-350 Hz, and
- apply the oscillating magnetic field to a tissue comprising cancer cells, including generate a sequence of pulses with a pulse length of approximately 250 ms.
A method for disrupting mitochondrial function or inducing apoptosis or cell death in cancer cells, the method comprising:
- causing, by controlling hardware, one or more magnets along (i) a first axis and a (ii) a second axis substantially orthogonal to the first axis to oscillate so as to generate an oscillating magnetic field;
- and
- applying the oscillating magnetic field to a tissue comprising cancer cells, including:
- generating a series of stimulus pulses of a first duration separated by inter-stimulus pulse intervals of a second duration, wherein the first duration is in a range of 10 milliseconds to 5 seconds, and the second duration is in a range of 10 milliseconds to 10 minutes, and
- ramping down a frequency of the oscillating magnetic field over a period of 250 ms.
A method for disrupting mitochondrial function or inducing apoptosis or cell death in cancer cells, the method comprising:
- causing, by controlling hardware, one or more magnets along (i) a first axis and a (ii) a second axis substantially orthogonal to the first axis to oscillate so as to generate an oscillating magnetic field;
- and
- applying the oscillating magnetic field to a tissue comprising cancer cells, including:
- generating a series of stimulus pulses of a first duration separated by inter-stimulus pulse intervals of a second duration, wherein the first duration is in a range of 10 milliseconds to 5 seconds, and the second duration is in a range of 10 milliseconds to 10 minutes,
- wherein the oscillating magnetic field has a peak to peak amplitude of 3 mT.
Dependencies are inferred from the claim text.