Method of forming a micro-capillary needle, micropipette or microneedle

A method of forming a micropipette, micro-capillary tube or microneedle for cellular or cellular gap use in a biological target comprising:

• with a first manufacturing process, forming a capillary tube having a tubular region of predetermined outer diameter and a distal end;
• and
• with a submicron-scale additive manufacturing process that is different from the first manufacturing process, forming a tip region with a substantially smaller diameter on and projecting from the distal end of the tubular region, wherein the tip region is formed with a sharp-pointed distal tip and with at least one flow of fluid material therethrough when the tip region is inserted into a cell, embryo or cellular gap in the biological target.

A method of forming a micro-capillary needle, micropipette or microneedle for cellular or cellular gap use in a biological target comprising:

• with a 3D printing manufacturing process, forming a capillary tube having a tubular region of relatively large outer diameter and an open tube distal end;
• and
• with a submicron-scale additive manufacturing process, forming a tip region on and projecting distally from the open tube distal end, wherein the tip region has a substantially smaller diameter than the tubular region, and wherein the tip region is formed with a sharp-pointed distal end tip and with at least one opening configured to permit flow of fluid material through said opening into a cell or cellular gap.