Intravascular devices and methods for delivery of fluids and therapeutic agents into blood vessel walls and intravascular structures
AssigneeInterVene, Inc.
InventorsFletcher T. Wilson, Jeffrey M. Elkins, Kent D. Dell, Herbert Mendoza, Michi E. Garrison
Life of this patent
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Abstract
Intravascular devices and methods for intramural delivery of dissection fluids and infusates are disclosed herein. In some embodiments, the systems include an infusion assembly that can access a vessel wall at a depth within a layer of the vessel wall and advance a tissue manipulation component at approximately the same depth within the vessel wall to create an intramural space within the vessel layer. The infusion assembly can further deliver an infusate that includes a therapeutic drug or other agent into the intramural space.
Claims13
A method of intravascularly delivering a therapeutic agent to a target site, the method comprising:
- positioning a distal portion of a catheter shaft of an infusion device at a target site within a vein of a patient;
- pressing an engagement surface of a housing at the distal portion of the catheter shaft against a venous wall such that the venous wall conforms to the engagement surface to position an exit port at the distal portion of the catheter shaft adjacent to the venous wall at the target site;
- actuating an adjustable height component positioned at the distal portion of the catheter shaft to transition a lowermost surface of a needle of the infusion device from a first height to a second height above a support surface at the distal portion of the catheter shaft, wherein, after the actuating, the adjustable height component is positioned to direct the needle into the venous wall with the lowermost surface at the second height;
- extending the needle through the exit port to penetrate the venous wall at the target site at the second height to access an intramural space within the venous wall;
- moving the needle within the intramural space in a direction generally aligned with a longitudinal axis of the catheter shaft;
- and
- delivering, through the needle, a drug to the intramural space within the venous wall.
A method of intravascularly delivering an anti-inflammatory drug to a blood vessel wall, the method comprising:
- positioning a distal portion of a catheter shaft of an infusion device at a target site within a vein of a patient;
- pressing an engagement surface of a housing at the distal portion of the catheter shaft against a venous wall such that the venous wall conforms to the engagement surface;
- extending a fluid delivery tool of the infusion device through an exit port at the distal portion of the catheter shaft to access an intramural space between layers of the venous wall at the target site;
- advancing the fluid delivery tool into the intramural space between the layers of the venous wall in a direction generally aligned with a longitudinal axis of the catheter shaft;
- delivering, through the fluid delivery tool, the anti-inflammatory drug to the intramural space between the layers of the venous wall to cause the anti-inflammatory drug to be absorbed by the layers of the venous wall at the target site to reduce inflammation adjacent to the target site;
- and
- actuating a height adjustment component positioned at the exit port of the catheter shaft to adjust an axial-most surface of the fluid delivery tool from a first set distance away from the engagement surface to a second set distance away from the engagement surface different from the first set distance.
Dependencies are inferred from the claim text.