Devices, systems, and methods for dry powder therapies
AssigneeVirginia Commonwealth University
InventorsPhilip Worth Longest, Michael Hindle, Dale Farkas, Susan Boc
Life of this patent
Estimating the term…
Abstract
Containment units, dry powder inhalers, delivery systems, and methods for the same are disclosed. Exemplary devices are configured to have inlets and outlets which are formed with the containment walls of a containment unit. Air jets formed by the configuration of inlet(s) and outlet(s) inside the containment unit create significant turbulence and deaggregate the powder. Delivery system components downstream of the containment unit may integrate the exiting aerosol plume with a low flow nasal cannula air stream for delivery to a subject.
Claims20
A dry powder inhaler (DPI) for use with at least one containment unit (CU) comprising one or more containing walls which enclose and protect a dry powder from external humidity and an interior space within the one or more containing walls that permits the dry powder to form a powder bed, wherein the dry powder is or contains a medicament for oral inhalation or nasal administration, the DPI comprising
- at least one inlet for making an inlet orifice in the one or more containing walls, the inlet orifice being configured to form an inlet air jet along a first straight geometric line coaxial with a center axis of the at least one inlet;
- and
- at least one outlet for making an outlet orifice in the one or more containing walls;
- wherein during a state of use, the powder bed lies outside the first straight geometric line coaxial with the center axis of the at least one inlet,
- wherein a direct unobstructed linear path exists between the at least one inlet and the at least one outlet,
- wherein a sum of cross sectional areas of all inlet orifices does not equal a sum of cross-sectional areas of all outlet orifices,
- wherein the at least one inlet has a first circular cross-section of constant diameter, and
- wherein the at least one outlet has a second circular cross-section of constant diameter.
A dry powder inhaler (DPI) for use with at least one containment unit (CU) comprising one or more containing walls which enclose and protect a dry powder from external humidity and an interior space within the one or more containing walls that permits the dry powder to form a powder bed, wherein the dry powder is or contains a medicament for oral inhalation or nasal administration, the DPI comprising
- at least one inlet for making an inlet orifice in the one or more containing walls, the inlet orifice being configured to form an inlet air jet along a first straight geometric line coaxial with a center axis of the at least one inlet;
- and
- at least one outlet for making an outlet orifice in the one or more containing walls, the outlet orifice being configured to form an outlet flow pathway along a second straight geometric line coaxial with a center axis of the at least one outlet;
- wherein during a state of use, the powder bed lies outside the first straight geometric line,
- wherein the at least one inlet and the at least one outlet are at opposite ends of the CU in the state of use,
- wherein a sum of cross sectional areas of all inlet orifices does not equal a sum of cross-sectional areas of all outlet orifices,
- wherein the at least one inlet has a first circular cross-section of constant diameter, and
- wherein the at least one outlet has a second circular cross-section of constant diameter.
A dry powder inhaler (DPI) for use with at least one containment unit (CU) comprising one or more containing walls which enclose and protect a dry powder from external humidity and an interior space within the one or more containing walls that permits the dry powder to form a powder bed, wherein the dry powder is or contains a medicament for oral inhalation or nasal administration, the DPI comprising
- a plurality of inlets for making respective inlet orifices in the one or more containing walls, wherein at least one inlet of the plurality of inlets is configured to form an inlet air jet along a first straight geometric line coaxial with a center axis of the at least one inlet;
- and
- one or more outlets, wherein a first outlet of the one or more outlets is configured for making a first outlet orifice in the one or more containing walls;
- wherein during a state of use, the powder bed lies outside the first straight geometric line.
A dry powder inhaler (DPI), comprising
- one or more containing walls which enclose and protect a dry powder from external conditions, wherein the dry powder is or contains a medicament for oral inhalation or nasal administration;
- at least one inlet that defines an inlet orifice in the one or more containing walls that has a fixed geometry which does not change from use of the DPI;
- at least one outlet that defines an outlet orifice in the one or more containing walls that has a fixed geometry which does not change from use of the DPI, wherein the inlet and outlet orifices are spaced apart;
- and
- an interior space within the one or more containing walls that permits the dry powder to form a powder bed,
- wherein the fixed geometry of the inlet orifice is configured to form an inlet air jet along a straight geometric line,
- wherein the powder bed lies outside the straight geometric line when the DPI is in an orientation of use, and
- wherein a direct linear path exists between the at least one inlet and the at least one outlet.
Dependencies are inferred from the claim text.