Pharmaceutical container and liquid composition
AssigneeSCHOTT Pharma AG & Co. KGaA
InventorsElmar Horsch, Tanja Woywod
Life of this patent
Estimating the term…
Abstract
A pharmaceutical container for drug delivery includes a barrel configured to slidably receive a stopper, the stopper having a proximal end suitable for contacting a plunger rod and a distal end suitable for contacting a pharmaceutical composition, the stopper having a circumferential surface partially contacting an inner surface of the barrel, a surface roughness of the inner surface of the barrel declines from the stopper's start position to its end position by at least 3% of at least one of Ra roughness or Rms roughness, the inner surface of the barrel having a surface roughness Ra of less than 100 nm.
Claims5
A pharmaceutical container for drug delivery, comprising:
- a stopper;
- and
- a barrel configured to slidably receive the stopper, the stopper having a proximal end suitable for contacting a plunger rod and a distal end suitable for contacting a pharmaceutical composition, the stopper having a circumferential surface partially contacting an inner surface of the barrel, the pharmaceutical container exhibiting a ratio of a break loose force (BLF) relative to a glide force (GF) of BLF/GF≤3 after accelerated aging for 105 days, wherein the stopper has one or more annular protrusions contacting the inner surface of the barrel when the stopper moves in a distal direction, the annular protrusions each have a rising edge and a falling edge in a proximal-distal direction, the rising edge of a most proximal annular protrusion and the inner surface of the barrel span angle X in the distal direction, the falling edge of a most distal annular protrusion and the inner surface span an angle A in a proximal direction, and the ratio X/A is at least 1.05.
A pharmaceutical container for drug delivery, comprising:
- a barrel configured to slidably receive a stopper, the stopper having a proximal end suitable for contacting a plunger rod and a distal end suitable for contacting a pharmaceutical composition, the stopper having a circumferential surface partially contacting an inner surface of the barrel, the pharmaceutical container exhibiting a break loose force (BLF0d) and a glide force (GF0d) before aging and a break loose force (BLF105d) and a glide force (GF105d) after accelerated aging for 105 days, wherein a relative difference in the break loose force of aged containers and non-aged containers defined by the formula (BLF105d−BLF0d)/BLF105d is less than 25% and/or a relative difference in the glide force of aged containers and non-aged containers defined by the formula (GF105d−GF0d)/GF105d is less than 25%.
Dependencies are inferred from the claim text.