Implants for cartilage and related devices and methods
AssigneeBioGend Therapeutics Co., Ltd.
InventorsChao-Ping Chen, Po-Wei Lee, Shih-Ting Hsu
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Abstract
The present disclosure relates to a transplantable implant comprising a biocompatible scaffold configured to be degraded over time when implanted to cartilage of a patient, the biocompatible scaffold comprising a plurality of pores, and a plurality of chondrocytes incorporated into the scaffold. In some embodiments, the implant has a longitudinal length to be implanted to an implantation hole created on the cartilage, wherein the implantation hole has an implantation depth, wherein the ratio of the full longitudinal length to the thickness of the cartilage is about 3 or less.
Claims26
A transplantable implant comprising:
- a biocompatible scaffold configured to be degraded over time when implanted to cartilage of a patient, the biocompatible scaffold comprising a first phase having a first plurality of pores and a second phase having a second plurality of pores, wherein the first phase has higher porosity than the second phase;
- a plurality of chondrocytes in the first phase,
- wherein the implant has a full longitudinal length to be implanted to an implantation hole created on the cartilage, wherein the implantation hole has an implantation depth, wherein the implant along the full longitudinal length has a first longitudinal length corresponding to the first phase and the cartilage portion in the implantation hole along the implantation depth and a second longitudinal length corresponding to the second phase and a mineral bone portion in the implantation hole along the implantation depth when the implant is implanted to the implantation hole, wherein the ratio of the first longitudinal length of the first phase to the full longitudinal length of the implant is from 0.35 about 0.6 to about 0.9, and
- wherein the first phase includes more collagen II than the second phase six months after the biocompatible scaffold degrades over time in the implantation hole.
Dependencies are inferred from the claim text.