Cell penetrating conjugates and methods of use thereof
AssigneeCity of Hope
InventorsAndreas Herrmann, Hua Yu, Piotr Marek Swiderski, John Ernest Shively, Lin Li
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Abstract
Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the cojugates.
Claims16
A protein covalently attached to one or more phosphorothioate nucleic acids, wherein 50% or more of the interneucleotide linkages of each phosphorothioate nucleic acid are phosphorothioate linkages, wherein the protein has a molecular weight of greater than 25 kDa, wherein the protein binds an intracellular target, and wherein the protein is non-cell penetrating in the absence of said one or more phosphorothioate nucleic acids.
Dependencies are inferred from the claim text.