Malaria pre-erythrocytic antigens as a fusion polypeptide and their use in the elicitation of a protective immune response in a host

A nucleic acid molecule encoding a chimeric antigenic polypeptide comprising a fusion of antigens of a Plasmodium parasite capable of infecting human or antigenic fragments thereof;

• wherein said antigens are selected from:
• a) a thrombospondin related anonymous protein (TRAP) antigen of SEQ ID NO:
• 23, SEQ ID NO:
• 24, SEQ ID NO:
• 26, or SEQ ID NO:
• 27,
• b) an 18-10 (inhibitor of cysteine protease (ICP) antigen of SEQ ID NO:
• 32, SEQ ID NO:
• 33, SEQ ID NO:
• 35, or SEQ ID NO:
• 36,
• c) an 11-10 (Ag45) antigen of SEQ ID NO:
• 79, SEQ ID NO:
• 80, SEQ ID NO:
• 82, or SEQ ID NO:
• 83, and
• d) an 11-09 (Ag40) antigen of SEQ ID NO:
• 70, SEQ ID NO:
• 71, SEQ ID NO:
• 73, SEQ ID NO:
• 74;
• and wherein said antigenic fragments have an amino acid sequence with at least 95% amino acid identity with said antigens.