Methods and compositions for inhibiting glyoxalase 1 (GLO1)
OwnerAbraham Palmer, Margaret Distler +1inventors
InventorsAbraham Palmer, Margaret Distler, Katherine M. J. McMurray
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Abstract
Methods and compositions are provided for treating or preventing a neurological disease or disorder using an inhibitor of Glyoxalase 1 (GLO1). In some embodiments, the inhibitor is a small molecule. In certain embodiments, the disease or disorder is a sleep disorder, a mood disorder such as depression, epilepsy, an anxiety disorder, substance abuse, substance dependence or substance such as an alcohol withdrawal syndrome.
Claims19
A method of treating a condition in a subject comprising administering to the subject a therapeutically effective amount of a composition comprising a Glo1 inhibitor, wherein the condition is an alcohol abuse disorder or alcohol withdrawal syndrome, and wherein the Glo1 inhibitor is an antibody, an inhibitory nucleic acid, a molecule having a glutathione structure, a 1-hydroxy-6,7-diphenylpyridin-2-one derivative (3d), a flavonoid, a curcumin, a benzothiazole derivative, a 4-(7-azaindole)-substituted 6-phenyl-N-hydroxypyridones, or 4,6-diphenyl-N-hydroxypyridone.
Dependencies are inferred from the claim text.