Lyophilized orally disintegrating tablet formulations of d-lysergic acid diethylamide for therapeutic applications

A method of making a solid oral immediate release formulation of LSD, consisting of the steps of:

• lyophilizing a single flash frozen stock solution consisting of LSD or a salt thereof, water, and excipients of a non-gelling matrix former of maltodextrin, filler, 1-5% weight percent a binder of hydroxypropyl methylcellulose, and buffer in a pre-formed mold;
• and
• forming an orally disintegrating tablet, wherein the LSD or salt thereof is present at less than 1% weight percent within the stock solution and wherein there is content uniformity of LSD or salt thereof within the tablet.

A method of treating an individual, including the steps of:

• administering a solid oral immediate release formulation of LSD of an orally disintegrating tablet, wherein the orally disintegrating tablet is produced by lyophilization of a single feedstock in a pre-formed mold to form the orally disintegrating tablet, wherein said feedstock consists of LSD or a salt thereof, water, a non-gelling matrix former of maltodextrin, a filler, and 1-5% weight percent of a binder of hydroxypropyl methylcellulose, and wherein the LSD or salt thereof is present at less than 1% weight percent of said feedstock and there is content uniformity of LSD or salt thereof within the tablet;
• and
• treating the individual.