Initial burst release controlled depot composition and a method thereof
AssigneeTionlab Therapeutics
InventorsDuck Soo Lim, Eun Joo Lee
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Abstract
A depot composition including a hydrophobic amino acid in a microsphere is provided. The depot composition is capable of controlling the initial burst release of an excess amount of the active ingredient in a formulation including a biodegradable polymer and an active ingredient. The depot composition has excellent suspending ability, and is able to uniformly and continuously obtain the effect of the active ingredient even when an ordinary user uses the composition as a formulation for injection.
Claims7
A depot composition comprising microspheres comprising an oil layer (O layer) comprising a biodegradable polymer and a hydrophobic amino acid,
- wherein the microspheres comprise a hydrophobic amino acid in an amount of less than 1.5 parts by weight in an oil phase solution, based on 100 parts by weight of the biodegradable polymer.
Dependencies are inferred from the claim text.