Polymeric delivery systems

A process of forming a polymeric delivery system, the process comprising forming self-assembled particles comprising a block copolymer and a biologic associated with the block copolymer in an aqueous solvent, wherein the block copolymer comprises a first block of a polyester copolymer of alternating monomers of a polyol monomer and a polycarboxylic acid monomer and a second block of a hydrophilic monomer or a hydrophilic polymer, wherein the second block is more hydrophilic than the first block and wherein the self-assembled particles are selected from the group consisting of polymersomes, polymeric micelles, and polyplexes;

• and
• wherein the first block has a chemical structure of formula (1):
• —[—CO—(CH2)m—R—(CH2)n—CO2—CH2—CH(OR′)—CH2—O—]x (1)
• wherein m and n are an integer from 1 to 30;
• x is an integer from 1 to 75;
• R is selected from the group consisting of —CH2—, —NH—, —NCH3—, —O—, —S—S—, —CH═CH—, —C≡C—, —CO2—, and —CONH—;
• and R′ is hydrogen or another replaceable pendant group.

A process of delivering a biologic to cells, the process comprising administering self-assembled particles in an aqueous solvent, the self-assembled particles comprising a block copolymer and the biologic associated with the block copolymer, wherein the block copolymer comprises a first block of a polyester copolymer of alternating monomers of a polyol monomer and a polycarboxylic acid monomer and a second block of a hydrophilic monomer or a hydrophilic polymer, wherein the second block is more hydrophilic than the first block and wherein the self-assembled particles are selected from the group consisting of polymersomes, micelles, and polyplexes;

• and
• wherein the first block has a chemical structure of formula (1):
• —[—CO—(CH2)m—R—(CH2)n—CO2—CH2—CH(OR′)—CH2—O—]x (1)
• wherein m and n are an integer from 1 to 30;
• x is an integer from 1 to 75;
• R is selected from the group consisting of —CH2—, —NH—, —NCH3—, —O—, —S—S—, —CH═CH—, —C≡C—, —CO2—, and —CONH—;
• and R′ is hydrogen or another replaceable pendant group.