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US 12,521,329 B2Granted
Antimicrobial mixture containing 4-(3-ethoxy-4-hydroxyphenyl) butan-2-one, and cosmetic composition containing same
AssigneeL'oreal
InventorsFlorence Menard-Szczebara, Sylvie Cupferman, Gael Malet, Julien Galvan
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Abstract
The invention relates to an antimicrobial mixture containing 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and an additional compound chosen from a monovalent or divalent metal salt of pyrithione, piroctone olamine, diazolidinylurea, a hexamidine compound, and imidazolidinylurea, and also to a cosmetic composition containing such a mixture. Application to caring for, making up and cleansing keratin materials.
Claims27
An antimicrobial mixture comprising 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and an additional compound chosen from:
- i) a monovalent or divalent metal salt of pyrithione;
- ii) piroctone olamine;
- iii) diazolidinylurea;
- iv) a hexamidine compound chosen from hexamidine diisethionate, hexamidine diparaben and hexamidine paraben;
- v) imidazolidinylurea;
- wherein when the additional compound is a monovalent or divalent metal salt of pyrithione, the antimicrobial mixture comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and the monovalent or divalent metal salt of pyrithione in amounts such that the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/pyrithione salt weight ratio ranges from 400 to 4500;
- when the additional compound is piroctone olamine, the antimicrobial mixture comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and piroctone olamine in amounts such that the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/piroctone olamine weight ratio ranges from 10 to 60;
- when the additional compound is diazolidinylurea, the antimicrobial mixture comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and diazolidinylurea in amounts such that the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/diazolidinylurea weight ratio ranges from 0.5 to 2.5;
- when the additional compound is the hexamidine compound, the antimicrobial mixture comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and the hexamidine compound in amounts such that the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/hexamidine compound weight ratio ranges from 5 to 85;
- when the additional compound is imidazolidinylurea, the antimicrobial mixture comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and imidiazolidinylurea in amounts such that the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/imidiazolidinylurea weight ratio ranges from 0.1 to 0.8;
- and wherein the amounts and ratios of the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and the additional compound are selected to produce synergistic antimicrobial activity.
8 more elements
Dependencies are inferred from the claim text.