Compositions, devices, systems, and methods for using a nanopore
AssigneeThe Regents of the University of California
InventorsMark A. Akeson, Roger Jinteh Arrigo Chen
Life of this patent
Estimating the term…
Abstract
Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
Claims10
A device comprising:
- a. a nanopore array comprising two or more nanopores, each nanopore disposed in a membrane;
- b. the nanopore array further comprising a sensor circuit in proximity to each nanopore;
- and
- c. a cavity in fluid communication with the two or more nanopores, the cavity substantially filled with a conductive liquid;
- wherein the conductive liquid shields the nanopore device from radiation.
A method for shielding a nanopore device from radiation, comprising:
- providing a nanopore array comprising two or more nanopores, each nanopore disposed in a membrane;
- the nanopore array further comprising a sensor circuit in proximity to each nanopore;
- and
- providing a cavity in fluid communication with the two or more nanopores, the cavity substantially filled with a conductive liquid;
- wherein the conductive liquid shields the nanopore array from radiation.
Dependencies are inferred from the claim text.