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US 12,516,349 B2Granted
Methods and systems for manufacturing viral vectors
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsStephen Michael Dicker, Julia Ruth Deuel, Vimal H. Vaidya
Life of this patent
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Abstract
Disclosed herein are methods and systems for manufacturing viral vectors (e.g., lentiviral vectors) using a static light scattering device in-line with a manufacturing process.
Claims8
A method for concentrating viral particles in a viral vector manufacturing process comprising filtering a solution comprising viral particles using tangential flow filtration in-line with a MALS device;
- wherein the MALS device determines the real-time concentration of the viral particles in solution and automates the filtering of the solution until the real-time concentration is substantially equal to a target concentration of the viral particles in the solution.
Dependencies are inferred from the claim text.