Methods and compositions for sensitization of tumor cells to immune therapy
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsTara Young, Christopher Daly, Gavin Thurston
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Abstract
Provided herein are methods and compositions related to the treatment or prevention of cancer (e.g., by targeting a tumor in a subject with cancer) by administering to a subject an agent that inhibits autophagy. In certain aspects, provided herein are methods of compositions related to methods of sensitizing cancer cells to tumor necrosis factor-alpha (TNF-α) mediated killing by contacting the cells or administering the agent that inhibits autophagy.
Claims20
A method of sensitizing a cancer cell to T cell-mediated killing, the method comprising contacting the cancer cell, in the presence of a T cell, with an agent that inhibits autophagy in the cancer cell, wherein the agent inhibits the expression or activity of at least one autophagy gene selected from ATG12 and ATG9A.
A method of treating cancer in a subject, the method comprising administering to the subject an agent that inhibits autophagy in a cancer cell in the subject and a cancer immunotherapy that induces T cell-mediated killing of cancer cells, wherein the agent inhibits the expression or activity of at least one autophagy gene selected from ATG12 and ATG9A.
A combination therapy comprising an agent that inhibits autophagy in a cancer cell and a cancer immunotherapy that induces T cell-mediated killing of cancer cells for use in treating cancer, wherein the agent inhibits the expression or activity of at least one autophagy gene selected from ATG12 and ATG9A.
Dependencies are inferred from the claim text.