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US 12,516,319 B2Granted
Compositions and methods for modulating TTR expression
AssigneeIonis Pharmaceuticals, Inc.
InventorsThazha P. Prakash, Punit P. Seth, Eric E. Swayze
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Abstract
Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine.
Claims14
A compound comprising a modified oligonucleotide and a conjugate group, wherein the modified oligonucleotide consists of 12 to 30 linked nucleosides, and is at least 95% complementary to an equal length portion of nucleobases of SEQ ID NO:
- 2 over the entire length, wherein the nucleobase sequence of the modified oligonucleotide comprises at least 8 contiguous nucleobases of SEQ ID NO:
- 12;
- and wherein the conjugate group is linked to the modified oligonucleotide by a conjugate linker;
- wherein the conjugate group comprises:
- wherein each n is, independently, from 1 to 20;
- and
- wherein the conjugate linker comprises:
4 more elements
Dependencies are inferred from the claim text.