Binding and catalytic molecules built from expanded DNA
OwnerSteven A Bennerinventor
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Abstract
This invention provides molecules that bind to and/or chemically transform a preselected target such as a protein molecule, where the molecules contain one or more “non-standard” nucleotides. These are nucleotide analogs that, when incorporated into oligonucleotides (DNA or RNA, collectively NA), present a pattern of hydrogen bonds that is different from the pattern presented by adenine, guanine, cytosine, and uracil or thymidine.
Claims14
A process for chemically transforming a preselected target, said target being a nucleic acid molecule comprising a one or more ribonucleotide units, and the chemical transformation being the cleavage of said molecule at one of said ribonucleotide units, said process comprising contacting said target with an oligonucleotide that comprises an oligonucleotide segment that comprises one or more nucleotides, wherein at least one nucleobase of said segment has a nucleobase selected from the group consisting of
- wherein R is the point of attachment of said nucleobase to said oligonucleotide, wherein said target is not Watson-Crick complementary to said oligonucleotide, and either wherein all of the carbohydrates of said oligonucleotide have D-configurations or wherein all of the carbohydrates of said oligonucleotide have L-configurations.
Dependencies are inferred from the claim text.