Composition comprising collagenase, calcium, histidine, and glycine, and method for stabilizing collagenase
AssigneeConnext Limited
InventorsChi Min Choi, Choong Sun Ryu, Sung Hee Kim
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Abstract
The present invention provides a composition comprising collagenase as an enzyme; calcium, histidine, and glycine as coenzymes, and a method for stabilizing enzymes, the method comprising the preparation of the composition by adding histidine and glycine to collagenase. According to the present invention, the enzyme composition and method for stabilizing enzymes can minimize or inhibit the agglutination of enzymes, maintain the concentration of freeze-dried enzymes even during long-term storage, and provide a formulation that has excellent rehydration time and hygroscopicity when restored to a liquid state, as well as superior enzyme activity.
Claims11
A lyophilized formulation comprising:
- collagenase as an enzyme;
- calcium as a coenzyme;
- histidine as a formulation additive;
- and
- glycine as another formulation additive.
Dependencies are inferred from the claim text.