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US 12,516,307 B2Granted
Modified porcine pancreatic elastase proteins
AssigneeOnchilles Pharma, Inc.
InventorHank Michael James Petrassi
Life of this patent
Estimating the term…
Abstract
Provided are modified porcine pancreatic elastase (PPE) proteins, including proproteins, comprising at least one amino acid alteration that reduces binding to serine protease inhibitors such as alpha-1 antitrypsin (A1AT), thereby increasing cancer-cell killing activity, and related pharmaceutical compositions and methods of use for treating diseases such as cancers.
Claims12
A modified porcine pancreatic elastase (PPE) protein,
- comprising an amino acid sequence that is at least 95% identical to SEQ ID NO:
- 5, and which retains the Q211F amino acid substitution of SEQ ID NO:
- 5, the residue numbering being defined by SEQ ID NO:
- 1.
1 more element
Dependencies are inferred from the claim text.