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US 12,516,122 B2Granted
Anti-VISTA antibodies and fragments
AssigneeJanssen Pharmaceutica NV
InventorsLinda Snyder, Gordon Powers
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel antibodies and fragments that bind to a V-domain Ig Suppressor of T cell Activation (VISTA), and methods of making and using same. Methods of use include methods of treatment of cancer, including leukemias, lymphomas, solid tumors and melanomas.
Claims36
An isolated or recombinant nucleic acid which encodes for an antibody or antibody fragment thereof comprising an antigen binding region that binds to a V-domain Ig Suppressor of T cell Activation (VISTA), which antibody:
- (i) comprises a VH domain comprising a VH CDR1 having the amino acid sequence of SEQ ID NO:
- 25, a VH CDR2 having the amino acid sequence of SEQ ID NO:26 and a VH CDR3 having the amino acid sequence of SEQ ID NO:27, and
- (ii) comprises a VL domain comprising a VL CDR1 having the amino acid sequence of SEQ ID NO:28, a VL CDR2 having the amino acid sequence of SEQ ID NO:
- 29 and a VL CDR3 having the amino acid sequence of SEQ ID NO:
- 30.
2 more elements
Dependencies are inferred from the claim text.