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US 12,516,109 B2Granted
Composition comprising anti-gliadin antibodies and method of use thereof to detect gliadin in a sample
AssigneeNIMA Partners, Inc.
InventorsJingqing Zhang, Shireen Taleghani Yates, Scott Erik Sundvor, Alim Seit-Nebi
Life of this patent
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Abstract
The present invention provides anti-gliadin antibodies and antibody fragments, and polypeptides encoding the antibodies or fragment. Also disclosed are methods and kits for the use of such antibodies, fragments, or polypeptides in detection of gliadin. Further provided are heavy chain and light chain variable sequences and associated sequences of complementarity-determining regions (CDRs).
Claims20
A composition comprising an isolated antibody or antibody fragment comprising:
- (1) a heavy chain variable region comprising a CDR1 of SEQ ID NO:3, a CDR2 of SEQ ID NO:4, and a CDR3 of SEQ ID NO:5 and a light chain variable region comprising a CDR1 of SEQ ID NO:8, a CDR2 of SEQ ID NO:9, and a CDR3 of SEQ ID NO:10;
- or
- (2) a heavy chain variable region comprising a CDR1 of SEQ ID NO:13, a CDR2 of SEQ ID NO:14, and a CDR3 of SEQ ID NO:
- 15 and a light chain variable region comprising a CDR1 of SEQ ID NO:
- 18, a CDR2 of SEQ ID NO:19, and a CDR3 of SEQ ID NO:20;
- wherein the antibody or antibody fragment binds to gliadin at an epitope defined by the amino acid sequence set forth in any one of SEQ ID NOs:21-32;
- and
- wherein the antibody or antibody fragment is linked to a solid support.
5 more elements
Dependencies are inferred from the claim text.