Reelin compositions for treatment of neurological disorders

A therapeutically effective amount of a viral vector composition encoding a Reelin recombinant protein fragment effective at inducing Reelin-dependent Apolipoprotein E Receptor (ApoER) activation and signaling, wherein the Reelin recombinant protein fragment is selected from:

• Reelin fragment repeat R3 through R4,
• Reelin fragment repeat R3 through R5,
• Reelin fragment repeat R3 joined to Reelin fragment repeat R5 (SEQ ID NO:
• 11, or Reelin fragment repeat R3 joined to Reelin fragment repeat R6 (SEQ ID NO:
• 9);
• wherein
• Reelin fragment repeat R3 is encoded by the nucleotide sequence consisting of SEQ ID NO:
• 2,
• Reelin fragment repeat R4 is encoded by the nucleotide sequence consisting of SEQ ID NO:
• 3,
• Reelin fragment repeat R5 is encoded by the nucleotide sequence consisting of SEQ ID NO:
• 4, and
• Reelin fragment repeat R6 is encoded by the nucleotide sequence consisting of SEQ ID NO:
• 5;
• and wherein
• a Loop Region encoded by a nucleotide sequence consisting of SEQ ID NO:
• 6 is disposed between Reelin fragment repeats R3 and R4, and
• a Loop Region encoded by a nucleotide sequence consisting of SEQ ID NO:
• 7 is disposed between Reelin fragment repeats R4 and R5.