Lappaconitine derivative and use thereof
AssigneeQgenetics Co., Ltd.
InventorsMun Seog Chang, Tae Hee Lee, Ha Young Kim, Jung Bin Min
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Abstract
The present invention pertains to a novel lappaconitine derivative, a method for producing same, and a pharmaceutical use thereof using osteogenesis-promoting activity. The lappaconitine derivative induces the differentiation of stem cells into osteoblasts, increases bone mineral density when administered to animal models of osteoporosis, and induces bone formation in animal models of bone fracture, and thus can be advantageously used for preventing, ameliorating, or treating bone-related diseases such as osteoporosis, as well as treating non-disease fractures caused by physical trauma.
Claims12
A compound represented by the following Formula 1, and a stereoisomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof:
- wherein R1 and R2 are each independently selected from the group consisting of hydrogen, a C1-C6 alkyl, a thioalkyl, an arylalkyl, a hydroxyalkyl, a dihydroxyalkyl, a hydroxy alkylarylalkyl, a dihydroxyalkylarylalkyl, an alkoxyalkyl, an acyloxyalkyl, an aminoalkyl, an alkylaminoalkyl, an alkoxycarbonylaminoalkyl, an acylaminoalkyl, an arylsulfoneamidoalkyl, an allyl, a dihydroxyalkylallyl, a dioxolanylallyl, a caralkoxyalkyl, methyl, ethyl, isopropyl, t-butyl, and phenyl.
A pharmaceutical composition for preventing or treating a bone-related disease, comprising a compound represented by the following Formula 1, and a stereoisomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof as an active ingredient:
- wherein R1 and R2 are each independently selected from the group consisting of hydrogen, a C1-C6 alkyl, a thioalkyl, an arylalkyl, a hydroxyalkyl, a dihydroxyalkyl, a hydroxy alkylarylalkyl, a dihydroxyalkylarylalkyl, an alkoxyalkyl, an acyloxyalkyl, an aminoalkyl, an alkylaminoalkyl, an alkoxycarbonylaminoalkyl, an acylaminoalkyl, an arylsulfoneamidoalkyl, an allyl, a dihydroxyalkylallyl, a dioxolanylallyl, a caralkoxyalkyl, methyl, ethyl, isopropyl, t-butyl, and phenyl.
Dependencies are inferred from the claim text.