Derivatives of aryl hydrocarbon receptor agonists

A method of treating an inflammatory disease, comprising:

• administering a compound of Formula (IV) or (V) to a subject in need thereof:
• or a stereoisomer, salt, or tautomer thereof, wherein:
• R1, R2, R3, R4, R5 R6, R7, and R8, are each independently hydrogen, deuterium, alkyl, halo, perfluoroalkyl, alkynyl, alkenyl, alkoxy, cycloalkoxy, thioalkyl, thiocycloalkoxy, perfluoroalkoxy, perfluorothioalkyl, hydroxyl, ester, amido, carboxyl, carbamoyl, sulfonyl amido, acylsulfonyl amido, sulfonyl, sulfinyl, sulfonyl urea, amino, thioester, nitrile, nitro, azido, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• R11a is halo, 4-8 membered heterocycloalkyl, 5-8 membered heteroaryl, —OH, —OX—, —SX—, —S(O)2X—, —NX2—, —OC(═O)X—, or —OC(═O)NX2—;
• R11b is 4-8 membered heterocycloalkyl, 5-8 membered heteroaryl, or —NX2—, wherein the 4-8 membered heterocycloalkyl of R11a or R11b is optionally substituted;
• X is each independently hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C1-C6 haloalkyl, C1-C10 heteroalkyl, —S(O)2OH, aryl, or 3-8 membered heterocycloalkyl;
• wherein the C1-C10 alkyl and C1-C10 heteroalkyl are optionally substituted with carboxyl, —NHS(═O)2Y—, —NHC(═O)OY—, or —NHC(═O)Y—;
• wherein the 3-8 membered heterocycloalkyl of X is optionally substituted with C1-C6 alkyl, C1-C4 amino, halo, —C(═O)Y—, or —C(═O)OY—;
• Y is each independently H, C1-C6 perfluoroalkyl, or C1-C6 alkyl;
• R12a and R12b, are each independently hydrogen or C1-C6 alkyl;
• R10 is O, NZ, or NNZ2;
• and
• Z is each independently hydrogen, hydroxyl, aryl, or C1-C4 alkyl, wherein C1-C4 alkyl is optionally substituted with aryl,
• wherein the inflammatory disease is an inflammatory bowel disease.