Application of glutamine derivative in preparation of animal feed additive
AssigneeWisorig Technologies Pte. Limited
InventorsXianfeng Peng, Huacheng Huang
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Abstract
Provided herein is an application of a glutamine derivative in preparation of an animal feed additive, specifically, the application of a glutamine derivative the structure of which is shown in the following formula (I) or racemates, stereoisomers, geometric isomers, tautomers, solvates and feed-acceptable salts of the glutamine derivative in animal feed additives. Results of animal breeding tests show that the glutamine derivative or racemates, stereoisomers, geometric isomers, tautomers, solvates, feed acceptable salts and other compounds thereof may be used as animal feed additives and have good effects in improving animal growth, feed conversion and other production performances.
Claims20
A method of improving animal production performance, wherein the method comprises administering an animal feed additive to an animal;
- wherein the improved production performance of the animal is improved feed conversion efficiency compared to an animal not administered with the animal feed additive;
- and wherein the animal feed additive comprises a glutamine derivative having a structure of formula (I), a racemate thereof, a stereoisomer thereof, a geometric isomer thereof, a tautomer thereof, a solvate thereof, or a feed acceptable salt thereof:
- wherein, Y is a C1-C20 alkoxyl group or OH;
- X is a nitrogen-containing C4-C10 cycloalkyl group, a NHC1-C20 alkyl group, or a N(C1-C20 alkyl group)2;
- R1 is R1aC(═O), R1bC(═O), R1aS(═O)2, R1bS(═O)2, or H;
- and R2 is R2aC(═O), R2bC(═O), R2aS(═O)2, or R2bS(═O)2;
- R1b is a C1-C20 alkyl group or a C3-C7 cycloalkyl group, and R2b is a C3-C7 cycloalkyl group, wherein the C3-C7 cycloalkyl group is optionally substituted with one, two, three, four, or five R3;
- R3 is —OH, —NH2, —CN, —SH, or —X1, wherein X1 is selected from F, Cl, Br, or I;
- each of R1a and R2a is independently an unsubstituted C6-C12 aryl group, a C5-C12 heteroaryl group, a —(C1-C4 alkylidene)-C6-C12 aryl group, or a —(C1-C4 alkylidene)-C5-C12 heteroaryl group, wherein the C5-C12 heteroaryl group, —(C1-C4 alkylidene)-C6-C12 aryl group, or —(C1-C4 alkylidene)-C5-C12 heteroaryl group is optionally substituted with one, two, three, four, or five R4;
- and
- R4 is —OH, —NH2, —NO2, —CN, —SH, —X2, a —C1-C5 alkoxy group, a —C1-C5 alkyl group, or a —C1-C5 alkyl group substituted with X2, wherein X2 is selected from F, Cl, Br, or I.
A method of improving animal production performance, wherein the method comprises administering an animal feed additive to an animal;
- and wherein the animal feed additive comprises a glutamine derivative having a structure of formula (I), a racemate thereof, a stereoisomer thereof, a geometric isomer thereof, a tautomer thereof, a solvate thereof, or a feed acceptable salt thereof:
- wherein, Y is a C1-C20 alkoxyl group or OH;
- X is a nitrogen-containing C4-C10 cycloalkyl group, a NHC1-C20 alkyl group, or a N(C1-C20 alkyl group)2;
- wherein R1 is R1bC(═O) or H;
- R2 is R2bC(═O);
- R1b is a C1-C20 alkyl group or a C3-C6 cycloalkyl group, R2b is a C3-C6 cycloalkyl group, wherein the C1-C20 alkyl group or C3-C6 cycloalkyl group is optionally substituted with one, two, three, four, or five R3;
- and R3 is —OH, —NH2, —CN, —SH, or —X1, wherein X1 is selected from F, Cl, Br, or I.
A method of improving animal production performance, wherein the method comprises administering an animal feed additive to an animal;
- and wherein the animal feed additive comprises a feed acceptable salt of a glutamine derivative having a structure of formula (I):
- wherein, Y is a C1-C20 alkoxyl group or OH;
- X is a nitrogen-containing C4-C10 cycloalkyl group, a NHC1-C20 alkyl group, or a N(C1-C20 alkyl group)2;
- R1 is R1aC(═O), R1bC(═O), R1aS(═O)2, R1bS(═O)2, or H;
- and R2 is R2aC(═O), R2bC(═O), R2aS(═O)2, or R2bS(═O)2;
- R1b is a C1-C20 alkyl group or a C3-C7 cycloalkyl group, and R2b is a C3-C7 cycloalkyl group, wherein the C3-C7 cycloalkyl group is optionally substituted with one, two, three, four, or five R3;
- R3 is —OH, —NH2, —CN, —SH, or —X1, wherein X1 is selected from F, Cl, Br, or I;
- each of R1a and R2a is independently a C6-C12 aryl group, a C5-C12 heteroaryl group, a —(C1-C4 alkylidene)-C6-C12 aryl group, or a —(C1-C4 alkylidene)-C5-C12 heteroaryl group, wherein the C6-C12 aryl group, C5-C12 heteroaryl group, —(C1-C4 alkylidene)-C6-C12 aryl group, or —(C1-C4 alkylidene)-C5-C12 heteroaryl group is optionally substituted with one, two, three, four, or five R4;
- and
- R4 is —OH, —NH2, —NO2, —CN, —SH, —X2, a —C1-C5 alkoxy group, a —C1-C5 alkyl group, or a —C1-C5 alkyl group substituted with X2, wherein X2 is selected from F, Cl, Br, or I, and
- wherein the feed acceptable salt is a Zn2+, Cu2+ or Ca2+ salt.
Dependencies are inferred from the claim text.