Crystal form of reduced coenzyme Q10 and preparation method therefor

A method for preparing a crystal form of reduced coenzyme Q10, wherein the crystal form of reduced coenzyme Q10 has an endothermic peak at 52±2° C. in a differential scanning calorimetry trace with a heating rate of 10 k/min, and has an X-ray powder diffraction pattern as shown in FIG. 1;

• and
• the method comprises:
• mixing and dissolving reduced coenzyme Q10 with a cyclic ether solvent under heating, adding a mixed solution of a fluorine-containing alcohol solvent and an organic base, and performing crystallization by cooling to obtain a crystal form of reduced coenzyme Q10;
• wherein the crystallization is performed at a temperature of 0° C. to 20° C.;
• the reduced coenzyme Q10 and the cyclic ether solvent are in a ratio of 1 g:(2-10) mL;
• the cyclic ether solvent and the fluorine-containing alcohol solvent are in a volume ratio of 1:(1-5);
• and
• the organic base is 5% to 10% by mass of the reduced coenzyme Q10;
• wherein the cyclic ether solvent is selected from the group consisting of 2-methyltetrahydrofuran, tetrahydrofuran, and a combination thereof;
• the fluorine-containing alcohol solvent is selected from the group consisting of trifluoromethanol, trifluoroethanol, trifluoropropanol, trifluorobutanol and a combination thereof;
• and
• the organic base is triethylamine.