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US 12,516,007 B2Granted
Downstream processing of fatty alcohol compositions produced by recombinant host cells
AssigneeGenomatica, Inc.
InventorsMyong Ko, Haibo Wang, Patricia J. Cole, Perry Y. Liao, Simon Li
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Abstract
The disclosure relates to downstream processing of fatty alcohol (FALC) and provides a novel purification method that provides FALC at high purity and yield.
Claims25
A method of purifying a fatty alcohol (FALC) composition, the method comprising:
- (a) producing a starting material comprising FALC and saponifiable impurities by fermentation of a microorganism grown in a fermentation broth, and wherein the saponifiable impurities comprise free fatty acids (FFA), fatty-fatty esters (FFE), and carbonyl-containing compounds;
- (b) adding a strong base to the starting material to generate a first mixture;
- and
- (c) evaporating the first mixture to generate a second mixture enriched for FALC;
- wherein, prior to adding the strong base, the starting material is optionally evaporated.
2 more elements
Dependencies are inferred from the claim text.