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US 12,515,222 B2Granted
Diagnostic system for hemoglobin analysis
AssigneeCase Western Reserve University
InventorsUmut Gurkan, Arwa Fraiwan, Peter Galen
Life of this patent
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Abstract
A diagnostic system detects and/or measures hemoglobin variants in blood of subject, such as HbA1c, to determine blood glucose concentration in the subject.
Claims20
A cartridge for a diagnostic system for detecting hemoglobin in a patient sample, comprising:
- a microchannel extending between first and second buffer pools that each have a buffer solution exhibiting an affinity to non-glycosylated hemoglobin;
- an electrophoresis strip positioned within the microchannel and structured to receive at least a portion of the patient sample, the electrophoresis strip having first and second ends positioned in the first and second buffer pools, respectively, and in fluid communication with the buffer solution in the respective first and second buffer pools;
- a first electrode exposed to the buffer solution in the first buffer pool;
- a second electrode exposed to the buffer solution in the second buffer pool, the first and second electrodes configured to generate an electric field across the electrophoresis strip;
- and
- the generation of the electric field across the electrophoresis strip inducing migration and separation of one or more bands of hemoglobin types in the patient sample.
3 more elements
Dependencies are inferred from the claim text.