# US 12,515,014 B2 · Self-expanding cannula > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,515,014 B2 - Document ID: US12515014B2 - Status: Granted - Kind: B2 - Application number: 17/142,375 - Filed: 2021-01-06 - Published: 2021-04-29 - Granted: 2026-01-06 - Earliest claimed: 2013-07-18 - Assignees: University of Maryland, Baltimore; University of Maryland, Baltimore County - Applicants: University of Maryland, Baltimore; University of Maryland, Baltimore County - Inventors: Zhongjun Wu; Bartley P. Griffith; Jun Ding - Web page: https://patentgrep.com/patent/US12515014B2 ## CPC - A61M 25/003: {characterized by features relating to least one lumen located at the distal part of the catheter, e.g. filters, plugs or valves (catheter tips A61M25/0067)} - A61M 1/3659: {Cannulae pertaining to extracorporeal circulation} - A61M 25/005: {with embedded materials for reinforcement, e.g. wires, coils, braids} - A61M 25/04: in the body, e.g. expansible {(A61M25/10, A61M16/0488 take precedence)} - A61M 2025/0024: {Expandable catheters or sheaths} - A61M 2025/0031: {characterized by lumina for withdrawing or delivering, i.e. used for extracorporeal circuit treatment} - A61M 2025/0035: {characterized by a variable lumen cross-section by means of a resilient flexible septum or outer wall} - A61M 2025/0039: {characterized by lumina being arranged coaxially} - A61M 2025/0059: {having means for preventing the catheter, sheath or lumens from collapsing due to outer forces, e.g. compressing forces, or caused by twisting or kinking} - A61M 2205/0266: Shape memory materials - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract Disclosed is a self-expanding cannula, systems using such cannulae, and methods of their use. The cannulae may comprise single lumen cannula (“SLC”) configurations and double lumen cannula (“DLC”) configurations, and include at least a first cannula and a self-expanding wire frame attached to the first cannula. Self-expanding wire frame is automatically expandable from a compressed state (providing a reduced cannula diameter as it is moved through a patient's body to the site at which it is to be deployed) to an expanded state (which increases the diameter of the cannula to the diameter intended for its normal use). The expanded wire frame provides radial support to prevent a drainage canal (whether a patient's blood vessel or a portion of the system inserted into the patient's blood vessel) from collapsing as fluid is drained from the patient. ## Claims ### Claim 1 A system for fluid handling of a patient's blood, comprising: a first cannula having a distal first cannula end and a proximal first cannula end opposite said distal first cannula end, said distal first cannula end having a tapered wall portion; a self-expanding wire frame defining an open face at a distal wire frame end and having a proximal wire frame end opposite said distal wire frame end, said proximal wire frame end being embedded within said tapered wall portion of said distal first cannula end, said wire frame comprising a continuous helical and zig-zag pattern, said wire frame having a first diameter and being automatically expandable to a maximum diameter when positioned to collect blood from the patient's body, wherein said maximum diameter is selected to be 1 to 2 mm smaller than a diameter of the patient's superior vena cava, wherein said open face is expandable to said maximum diameter of said wire frame and wherein the first cannula and the self-expanding wire frame together form a blood withdrawal lumen; and a second cannula having a distal second cannula end and a proximal second cannula end opposite said distal second cannula end, said second cannula having an outer diameter sized to allow said second cannula to be positioned in and to move within said first cannula and said wire frame, wherein said second cannula forms a blood infusion lumen extending coaxially through said blood withdrawal lumen. ### Claim 2 (depends on 1) The system of claim 1, wherein said self-expanding wire frame is automatically expandable to said maximum diameter in response to warming from the patient's body temperature. ### Claim 3 (depends on 2) The system of claim 2, said wire frame being compressible to a reduced diameter when exposed to a temperature less than a human's normal body temperature, said reduced diameter being sufficiently small to allow passage of said wire frame through a portion of the patient's circulatory system. ### Claim 4 (depends on 1) The system of claim 1, said maximum diameter being selected so as to provide radial support to a vessel in which said wire frame is positioned against collapse during suctioning of blood through said wire frame and said first cannula. ### Claim 5 (depends on 1) The system of claim 1, wherein said distal first cannula end tapers toward a reduced diameter at a distal face of said distal first cannula end. ### Claim 6 (depends on 1) The system of claim 1, further comprising linkages between longitudinally adjacent segments of said zig-zag pattern. ### Claim 7 (depends on 1) The system of claim 1, further comprising a port extending into a sidewall of said first cannula. ### Claim 8 (depends on 7) The system of claim 7, wherein said second cannula is further configured to allow said second cannula to be positioned in and to move within said port, said first cannula and said wire frame. ### Claim 9 (depends on 8) The system of claim 8, wherein said distal second cannula end is radio-opaque. ### Claim 10 (depends on 8) The system of claim 8, said second cannula further comprising a second wire frame embedded within the distal second cannula end. ### Claim 11 (depends on 10) The system of claim 10, wherein said second wire frame is automatically expandable from a reduced second wire frame diameter to an enlarged second wire frame diameter in response to warming from the patient's body temperature. ### Claim 12 (depends on 8) The system of claim 8, further comprising a sheath having a distal sheath having an internal diameter selected to allow said first cannula, said wire frame, and said second cannula to be positioned within said sheath. ### Claim 13 (depends on 12) The system of claim 12, wherein said self-expanding wire frame is sufficiently flexible so as to radially compress to a reduced diameter when said first cannula, said wire frame, and said second cannula are positioned within said sheath and to automatically expand to said maximum diameter upon removal of said sheath. ### Claim 14 (depends on 12) The system of claim 12, said sheath having a line of weakening extending along a longitudinal length of said sheath and configured to allow said sheath to be removed from said first cannula, said wire frame, and said second cannula after placement of said first cannula, said wire frame, said second cannula within a blood vessel of the patient. ### Claim 15 (depends on 12) The system of claim 12, further comprising an introducer having an outer diameter sized to allow said introducer to extend through said second cannula toward and through said distal second cannula end. ### Claim 16 (depends on 15) The system of claim 15, said introducer having a tapered, distal introducer end. ### Claim 17 (depends on 8) The system of claim 8, wherein said distal second cannula end is distally positionable a sufficient distance away from said distal wire frame end so as to prevent extracorporeal recirculation of fluid that has been drained from and returned to the patient by the system.