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US 12,514,960 B2Granted
Antimicrobial coatings
AssigneeMicroVention, Inc.
InventorsGregory M. Cruise, Steve Plotkin, Petr Vasek
Life of this patent
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Abstract
Described are coatings for medical devices and methods of forming same.
Claims16
A method of preparing an antimicrobial-coated catheter comprising:
- forming a base coat by dissolving a mixture of tetrahydrofurfuryl acrylate, a monomer comprising a functional group amenable to further derivatization, an initiator and a solvent and polymerizing the mixture to form a base coat copolymer;
- wherein the base coat copolymer is further modified to contain a plurality of reactive moieties;
- and
- forming a top coat by dissolving at least one antimicrobial compound, a polymer, or a combination thereof;
- wherein the top coat comprises a copolymer reaction product of a mixture comprising [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide, 4-hydroxybutyl acrylate, an initiator and a solvent and polymerizing the mixture to form top coat copolymer;
- and
- wherein the top coat comprises a decorated top coat formed from a reaction product of a mixture comprising the top coat copolymer reaction product and 2-isocyanatoethyl acrylate;
- applying the base coat to the catheter;
- and
- applying the top coat to the catheter.
7 more elements
The method of 1, wherein said functional group comprises at least one of hydroxyl, amine, carboxylic acid groups.
Dependencies are inferred from the claim text.