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US 12,514,956 B2Granted
Rotating frame apparatus and biocompatible scaffold construct
AssigneeEmbody, Inc.
InventorsMichael P. Francis, Kyle Christensen
Life of this patent
Estimating the term…
Abstract
A biocompatible scaffold construct includes a plurality of collagen fiber strands, a first portion of which have been coated by a first biocompatible solution and, optionally, a second portion of which have been coated by a second biocompatible solution different than the first biocompatible solution. The coatings may include cells. And the scaffold is constructed on rotating frame collectors.
Claims3
A scaffold construct, comprising:
- a plurality of substantially aligned collagen microfibers arranged in multiple layers, wherein the collagen microfibers are spaced on average between about 100 to about 1000 microns with respect to each other;
- wherein a first portion of the collagen microfibers is coated by a first biocompatible solution comprising cells suspended in hyaluronic acid solution and a second portion of the collagen microfibers is coated by a second biocompatible solution different from the first biocompatible solution;
- and
- wherein the first portion is disposed in a first longitudinal portion of the scaffold and the second portion is discretely disposed in a second longitudinal portion of the scaffold different from the first longitudinal portion.
1 more element
A scaffold construct, comprising:
- a plurality of collagen microfibers fabricated on a rotating frame and arranged in a continuous loop configuration, wherein the microfibers are substantially parallel to one another and spaced on average between about 100 to about 1000 microns with respect to each other;
- the collagen microfibers are coated with a first biocompatible solution and a second biocompatible solution, the first and second biocompatible solutions being different from each other;
- and
- wherein the scaffold construct has mechanical properties approximating or exceeding those of human musculoskeletal tissues.
1 more element
A scaffold construct, comprising:
- a plurality of collagen microfibers arranged in an organized configuration in a continuous loop,
- wherein the microfibers are spaced on average between about 100 to about 1000 microns with respect to each other and have properties comparable to biological tissue;
- wherein the collagen microfibers are coated with a first biocompatible hydrogel comprising fibrin gel and a second biocompatible hydrogel different from the first biocompatible hydrogel;
- and
- wherein the first biocompatible hydrogel is formed by combining a first biocompatible solution with a second biocompatible solution during fabrication.
2 more elements
Dependencies are inferred from the claim text.