Recombinant non-pathogenic marek's disease virus constructs encoding infectious laryngotracheitis virus and infectious bursal disease virus antigens
AssigneeIntervet Inc.
InventorsStephanie Cook, Mohamad Morsey, Ian Tarpey, Iwan Verstegen, Paulus Jacobus Antonius Sondermeijer, Paul Vermeij
Life of this patent
Estimating the term…
Abstract
The present invention discloses novel recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express both Infectious Laryngotracheitis Virus protein antigens and an Infectious Bursal Disease virus protein antigen, and methods of their use in poultry vaccines.
Claims20
A recombinant herpesvirus of turkeys (rHVT) comprising a nucleic acid that comprises a nucleotide sequence that encodes an Infectious Laryngotracheitis Virus glycoprotein D (ILTV gD), a nucleotide sequence that encodes an Infectious Laryngotracheitis Virus glycoprotein I (ILTV gI), and a nucleotide sequence that encodes an Infectious Bursal Disease Virus viral protein 2 (IBDV VP2);
- wherein the nucleic acid sequence is located in a nonessential site in the rHVT genome;
- and wherein the nonessential insertion site is selected from the group consisting of the US2 site and the UL54.5 site;
- wherein the nucleic acid is configured to be transcribed in the opposite direction relative to respectively, a US2 gene or a UL54.5 gene of rHTV.
Dependencies are inferred from the claim text.