Compositions and methods for treating HIV infection and reversing HIV latency
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsRobbie B. Mailliard, Charles R. Rinaldo, Jr., Jan Kristoff
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Abstract
Disclosed herein are compositions and uses thereof for detecting HIV latency reversal, isolating cells with HIV latency reversal, treating HIV infection, and/or reversing latency in HIV infected CD4+ T cells. In some aspects, disclosed herein is a composition and uses thereof for treating HIV infection, wherein the composition comprises one or more mature monocyte-derived dendritic cells (MDGs) having an HIV peptide bound to a Class I major histocompatibility complex (MHC) molecule and a herpesvirus peptide bound to one or more Class II MHC molecules.
Claims8
A method of reversing HIV-1 latency in a CD4+ T cell in a subject, comprising:
- a) obtaining one or more mature monocyte-derived dendritic cells (MDCs) having a herpesvirus peptide bound to a Class II MHC molecule;
- and
- b) administering to the subject an effective amount of the one or more MDCs of step a) and thereby reversing the HIV-1 latency.
Dependencies are inferred from the claim text.