US 12,514,917 B2 · Senecavirus A virus strains and immunogenic compositions therefrom

Abstract

The present invention is directed to novel nucleotide sequences of Senecavirus A (“SVA”), including novel genotypes thereof, which are useful as live attenuated and other vaccine compositions for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine SVA genotypes and isolates. Diagnostic and therapeutic sequences are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include polynucleotide constructs that replicate in tissue culture and in host swine. The invention also provides for novel full length SVA genomes that can replicate efficiently in host animals and tissue culture.

Claims21

Dependent claims

An attenuated Senecavirus A (SVA) encoded by a DNA polynucleotide that is at least 95% identical, at a full-length nucleotide level, to SEQ ID NO:

1 or 2, and that includes:
(a) a thymine at position 33 in the 5′ UTR;
(b) a thymine at position 36 in the 5′ UTR;
(c) a thymine at position 37 in the 5′ UTR;
and
(d) an adenine at position 947 in the VP4 coding region with reference to SEQ ID NO:
1.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

17/626,337Filed 15 Jul 2020 · us provisional application

Priority

15 Jul 2019

Published

US 2022/0249650 A111 Aug 2022

Granted

6 Jan 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification21 codes

A61K 39/12
Medicinal preparations containing antigens or antibodies: viral antigens
A61K 39/125
Viral antigens: picornaviridae, e.g. calicivirus
A61K 39/39
Medicinal preparations containing antigens or antibodies: characterised by the immunostimulating additives, e.g. chemical adjuvants
A61P 31/14
Antivirals: for RNA viruses

Senecavirus A virus strains and immunogenic compositions therefrom

Life of this patent

Senecavirus A virus strains and immunogenic compositions therefrom

Life of this patent

Abstract

Claims21