Polycationic polymers for use in treating and detecting cancer
AssigneeDuke University
InventorsBruce A. Sullenger, Ibtehaj Naqvi, Ruwan Gunaratne, Rebekah White
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Abstract
Methods of treating cancer in a subject by administering a therapeutically effective amount of a polycationic polymer to the subject are provided. Methods of treating cancer in a subject by contacting a bodily fluid from a subject with a polycationic polymer are also provided. Methods of detecting cancer or metastasis of cancer by obtaining a sample from a subject and determining the level of circulating free DNA (cfDNA), cfRNA, inorganic polyphosphates or the number of exosomes or nucleosomes in the sample are also provided.
Claims10
A method of treating pancreatic cancer in a subject, the method comprising:
- administering a therapeutically effective amount of a polycationic polymer to the subject, wherein the polycationic polymer is selected from the group consisting of PPA-DPA, CDP, CDP-Im, PAMAM, and HDMBr;
- and
- surgically removing at least a portion of the cancer from the subject in conjunction with administering the polycationic polymer,
- wherein before administering the polycationic polymer and surgically removing at least a portion of the cancer;
- the method further comprises (a) obtaining a sample from a subject;
- (b) adding a polycationic polymer to the sample;
- (c) determining a level of at least one marker selected from exosomes and nucleosomes in the sample;
- and (d) selecting the subject for treatment when cancer is detected.
Dependencies are inferred from the claim text.