Pegylated menaquinol compositions and methods of treatment

A biologically active menaquinol derivative of the formulae I, II or III:

• wherein:
• m is an integer from 2 to 15;
• m1, where present, is an integer from 3 to 15;
• n is 7, 8, 9 or 10;
• R is H, or is selected from the group consisting of —C(O)C1-C6 alkyl, —C(O)(CH2)q—O—C(O)C1-C6 alkyl and —Z—(C═Y)(CH2)s—(OCH2CH2)—O—R1;
• R1 is H or —CH3;
• R2 is H or C1-C3 alkyl;
• q is 1, 2 or 3;
• s is 1, 2 or 3;
• Y is O, NR2 or S;
• Z is —C(O)CH2O—, —C(O)CH2NH— or is absent;
• and
• Z1 is —C(O)CH2O—, —C(O)CH2NH— or is absent.