Biofilm disruption

A method of treating a bacterial infection comprising a biofilm comprising Gram-negative bacteria, said method comprising locally administering to the bacterial infection an epoxytiglienone compound of formula (I):

• wherein
• R1 is selected from hydrogen and C1-6alkyl;
• R2 is selected from —OC1-8alkyl, —OC2-8alkenyl, —OC2-8alkynyl, —OC(O)C1-7alkyl, —OC(O)C2-7alkenyl and —OC(O)C2-7alkynyl;
• R3 is selected from —OH, —OC1-8alkyl, —OC2-8alkenyl, —OC2-8alkynyl, —OC(O)C1-7alkyl, —OC(O)C2-7alkenyl and —OC(O)C2-7alkynyl;
• R4 and R5 are independently selected from hydrogen and C1-6alkyl;
• R6 is selected from hydrogen, —C1-6alkyl, —C2-6alkenyl, —C2-6alkynyl, —C(O)C1-6alkyl, —C(O)C2-6alkenyl, —C(O)C2-6alkynyl, —C(O)C3-8cycloalkyl, —C(O)C1-6alkylC3-8cycloalkyl, —C(O)C2-6alkenylC3-8cycloalkyl, —C(O)C2-6alkynylC3-8cycloalkyl, —C(O)aryl, —C(O)C1-6alkylaryl, —C(O)C2-6alkenylaryl and —OC(O)C2-6alkynylaryl;
• R7 is selected from hydroxy, —OC1-6alkyl, —OC2-6alkenyl, —OC2-6alkynyl, —OC(O)C1-6alkyl, —OC(O)C2-6alkenyl, —OC(O)C2-6alkynyl, —C(O)C3-8cycloalkyl, —C(O)C1-6alkylC3-8cycloalkyl, —C(O)C2-6alkenylC3-8cycloalkyl, —C(O)C2-6alkynylC3-8cycloalkyl, —OC(O)aryl, —OC(O)C1-6alkylaryl, —C(O)C2-6alkenylaryl and —C(O)C2-6alkynylaryl;
• and
• R8 is selected from hydrogen and C1-6alkyl;
• or a pharmaceutically acceptable salt thereof.