Enteral feeding devices and related methods of use

An enteral feeding device for hydrolyzing triglycerides in a nutritional formula by exposing the nutritional formula to lipase, the device comprising:

• a body housing a chamber;
• a first opening configured to fluidly couple with a source of nutritional formula, allowing the nutritional formula to enter the device from the source and flow into the chamber;
• a second opening configured to fluidly couple with an enteral feeding tube, allowing the nutritional formula to exit the chamber and flow into the enteral feeding tube;
• a plurality of particles contained within the chamber, wherein lipase is bonded to the plurality of particles such that 5 mg to 500 mg of lipase is bonded per 1 g of the plurality of particles;
• a headspace contained within the chamber defining a space not occupied by the plurality of particles;
• and
• a first filter and a second filter, wherein the first filter and the second filter define opposite ends of the chamber, and at least one of the first filter and the second filter includes a plurality of pores, wherein each pore has a diameter ranging from about 100 μm to about 500 μm;
• wherein the particles have a mass density ranging from about 0.25 g/mL to about 0.5 g/mL;
• wherein the plurality of particles are configured to transition from a dry configuration to a wet configuration when exposed to the nutritional formula during an enteral feeding;
• and
• wherein the triglycerides in the nutritional formula are hydrolyzed as they pass through the plurality of particles contained within the chamber.