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US 12,514,829 B2Granted
Curcuminoid composites
AssigneeNutriventia Private Limited
InventorsVaibhavi Shah, Vijayendrakumar Redasani, Shajahan Abdul, Vishal Shah, Rajat Shah
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AssigneeNutriventia Private Limited
InventorsVaibhavi Shah, Vijayendrakumar Redasani, Shajahan Abdul, Vishal Shah, Rajat Shah
Estimating the term…
The present invention relates to a melt composite comprising one or more curcuminoids and a carrier selected from rice bran extract, mannitol, maltodextrin and mixtures thereof. The invention also provides a process for preparation of the melt composite, wherein the mixture of curcuminoids, rice bran extract, mannitol, maltodextrin and mixture thereof may be subjected to controlled conditions of heating and granulation. The melt composite may also be optionally comprised of one more excipient suitable for use for human consumption. Curcuminoid composites can be formulated in suitable solid, liquid or semisolid compositions. Curcuminoid composites and the compositions thereof, exhibit rapid dissolution and enhanced bioavailability.
A method for administering curcuminoids to a subject comprising orally administering to the subject a melt composite comprising one or more curcuminoids and a carrier, wherein the melt composite is prepared by melt granulation, melt extrusion, melt solidification, or melt spray congealing, wherein the melt composite does not include a synthetic polymer or a thermoplastic polymer, wherein the carrier is a mixture of rice bran extract and maltodextrin, and the ratio of the one or more curcuminoids to the mixture of rice bran extract and maltodextrin ranges from about 1:0.1 to about 1:20.
A method for providing improved bioavailability of curcuminoids to a subject in need thereof comprising orally administering to the subject once daily a melt composite comprising one or more curcuminoids and a carrier, wherein the melt composite is prepared by melt granulation, melt extrusion, melt solidification, or melt spray congealing, wherein the melt composite does not include a synthetic polymer or a thermoplastic polymer, wherein the carrier is a mixture of maltodextrin and rice bran extract, and the ratio of the one or more curcuminoids to the mixture of rice bran extract and maltodextrin ranges from about 1:0.1 to about 1:20.
Dependencies are inferred from the claim text.