Delayed disintegration-type capsule and method for producing same

A method for producing a delayed disintegration-type seamless capsule, the method comprising:

• discharging a core liquid from an innermost nozzle of a concentric triple nozzle into a cooling liquid composed of a cooled liquid oil;
• and
• simultaneously dropping an intermediate layer liquid from an intermediate nozzle disposed outside the innermost nozzle and an outermost layer liquid from an outermost nozzle to form a seamless capsule,
• wherein the core liquid comprises an active substance, an amphoteric surfactant, and a fat having a melting point of 40° C. or more,
• the intermediate layer liquid comprises a fat having a melting point of 45° C. or more, and
• the outermost layer liquid comprises a water-soluble natural polymer
• selected from the group consisting of gelatin, agar, gellan gum, carrageenan, furcellaran, pectin, chitosan, alginic acid, curdlan, starch, modified starch, pullulan, mannan, and mixtures thereof,
• wherein the amphoteric surfactant is lecithin, which is present in an amount of 5 to 50% by weight based on a total weight of the core and reduces an effect on the capsule's disintegration due to pH change in a body after the capsule is administered.