Dermal patch and systems, kits, and methods associated therewith

A topical dermal system for treating a closed wound, the topical system comprising:

• a dermal patch including
• a support layer having a top side and a bottom side opposite the top side, wherein the bottom side of the support layer is configured to face a skin of a patient;
• and
• a medicament depot attached to the support layer, the medicament depot including an effective amount of at least one medicament for treating a wound in the skin of the patient, wherein the medicament depot is made of a copolymer of Formula I as follows:
• wherein
• a is from 20 to 1000,
• b is from 20 to 1000,
• n is from 1 to 200,
• R1 and R3 are independently hydrogen or a C1-C4 hydrocarbon;
• R2 is a C1-C18 hydrocarbon or a hetero group containing, F, Cl, Br, I, N,P, Si and O, and
• R4 is hydrogen, a C1-C18 hydrocarbon or a hetero group containing, F, Cl, Br, I, N,P, Si and O;
• and
• a separate skin adhesive configured to be applied over the dermal patch to seal the dermal patch over the closed wound.

A method of treating a wound comprising:

• positioning a dermal patch over a wound, the dermal patch including
• a support layer having a top side and a bottom side opposite the top side, wherein the bottom side of the support layer is configured to face a skin of a patient;
• and
• a medicament depot attached to the support layer, the medicament depot including an effective amount of at least one medicament for treating a wound in the skin of the patient, wherein the medicament depot is made of a copolymer of Formula I as follows:
• wherein
• a is from 20 to 1000,
• b is from 20 to 1000,
• n is from 1 to 200,
• R1 and R3 are independently hydrogen or a C1-C4 hydrocarbon;
• R2 is a C1-C18 hydrocarbon or a hetero group containing, F, Cl, Br, I, N,P, Si and O, and
• R4 is hydrogen, a C1-C18 hydrocarbon or a hetero group containing, F, Cl, Br, I, N,P, Si and O;
• applying a separate topical adhesive over the dermal patch, the wound, and skin surrounding the wound to seal the dermal patch over the wound forming a sealed dermal system.

A kit for treating a wound in a patient's skin, the kit comprising:

• a dermal patch including
• a support layer having a top side and a bottom side opposite the top side, wherein the bottom side of the support layer is configured to face a skin of a patient;
• and
• a medicament depot attached to the support layer, the medicament depot including an effective amount of at least one medicament for treating a wound in the skin of the patient, wherein the medicament depot is made of a copolymer of Formula I as follows:
• wherein
• a is from 20 to 1000,
• b is from 20 to 1000,
• n is from 1 to 200,
• R1 and R3 are independently hydrogen or a C1-C4 hydrocarbon;
• R2 is a C1-C18 hydrocarbon or a hetero group containing, F, Cl, Br, I, N,P, Si and O, and
• R4 is hydrogen, a C1-C18 hydrocarbon or a hetero group containing, F, Cl, Br, I, N,P, Si and O;
• and
• a separate topical adhesive configured to be applied over the dermal patch to seal the dermal patch over the closed wound.