US 12,514,592 B2 · Apparatus for displacement of blood to mitigate peripheral nerve neuropathy

Abstract

Embodiments of the present invention are directed to devices, systems and methods adapted for implementing intermittent displacement of blood to mitigate peripheral nerve neuropathy such as that induced by chemotherapeutic agents (i.e., chemotherapy-induced neuropathy (CIN)) that are administered to a patient. Such devices, systems and methods advantageously provide for precise, uniform and controlled blood flow occluding (and optionally blood displacing) compression along irregular surfaces of an appendage of a patient. Such precise, uniform and controlled blood occluding compression is imparted upon the epidermal and dermis skin layers within the aforementioned areas of a patient's extremities to decrease the time that free nerve endings located in the epidermal and encapsulated nerve endings located in the dermis skin layers are exposed to nerve damaging chemotherapy chemicals, thereby substantially decreasing CIN caused by prolonged exposure to such chemicals.

Claims29

Dependent claims

An apparatus for controlling operational parameters of a compression exertion device having a body part of a patient disposed within an interior space thereof during administering of a therapeutic agent to the patient, the apparatus comprising a controller operable for performing:

system-managed pressurization of a tissue-treating compression-inducing medium within the interior space of the compression exertion device, wherein said system-managed pressurization is performed:
for exerting a compressive pressure by the compression exertion device on the body part;
and
as a function of said administration of the therapeutic agent, wherein the controller monitors said administration of the therapeutic agent and manages exertion of the compressive pressure as a function of said administration of the therapeutic agent to reduce adverse therapy treatment outcomes arising from at least one of exposure of nerve endings within the body part to the therapeutic agent and oxygen deprivation of a skin layer of the body part resulting from exertion of the compressive pressure on the body part.

1 more element

A system for mitigating neuropathy in a body part of a patient undergoing administration of a therapeutic agent, the system comprising:

a compression exertion device having an interior space adapted for receiving at least a portion of a body part of the patient;
a tissue-treating compression-inducing medium;
and
a controller operably attachable to the compression exertion device for enabling transmission of the tissue-treating compression-inducing medium therebetween, wherein the controller is operable for performing:
system-managed pressurization of the tissue-treating compression-inducing medium within the interior space of the compression exertion device, wherein said system-managed pressurization is performed:
for exerting a compressive pressure by the compression exertion device on the body part;
and
as a function of said administration of the therapeutic agent, wherein the controller monitors said administration of the therapeutic agent and manages exertion of the compressive pressure as a function of said administration of the therapeutic agent to reduce adverse therapy treatment outcomes arising from at least one of exposure of the nerve endings within the body part to the therapy agent and oxygen deprivation of a skin layer of the body part resulting from exertion of the compressive pressure on the body part.

5 more elements

Dependencies are inferred from the claim text.

Apparatus for displacement of blood to mitigate peripheral nerve neuropathy

Life of this patent

Apparatus for displacement of blood to mitigate peripheral nerve neuropathy

Life of this patent

Abstract

Claims29