Use of vapor deposition coated flow paths for improved analytical analysis
AssigneeWaters Technologies Corporation
InventorsXiaoxiao Liu, Anna Boardman, Mathew H. DeLano, Matthew A. Lauber
Life of this patent
Estimating the term…
Abstract
A device for processing samples is disclosed. Interior surfaces of the device, which come in contact with fluids, define wetted surfaces. A portion of the wetted surfaces are coated with an alkylsilyl coating having the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20—, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.
Claims12
A sample preparation device comprising wetted surfaces defining a fluidic flow path extending within an interior of the sample preparation device,
- wherein a material forming the wetted surfaces of the fluidic flow path prior to coating is formed of a polymeric material;
- and
- wherein at least a portion of the wetted surfaces of the fluidic flow path is coated with a coating comprising a first layer formed by infiltrating vaporized bis(trichlorosilyl) ethane or bis(trismethoxysilyl) ethane through the fluidic flow path followed by a second layer formed by vapor depositing (3-glycidyloxypropyl) trimethoxysilane followed by hydrolysis.
Dependencies are inferred from the claim text.