Biocompatible nanofiber adhesive
AssigneeVitaloc Ltd
InventorEyal Sheetrit
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Abstract
A nanofiber comprising a cross-linkable protein polymer and a transglutaminase. A method for producing a nanofiber, the method comprising: combining a first solution comprising a cross-linkable protein polymer and a second solution comprising a transglutaminase to produce a liquid electro spinning mixture (LEM) characterized by an environment that is unsuitable for the transglutaminase to be enzymatically active on the cross-linkable protein polymer; and electro spinning the LEM to form a nanofiber comprising the TGase and the cross-linkable protein polymer.
Claims34
A nanofiber produced by a method comprising:
- combining a first solution comprising a cross-linkable protein polymer and a second solution comprising a transglutaminase to produce a liquid electrospinning mixture (LEM), wherein the LEM is characterized by an environment that is unsuitable for said transglutaminase to be enzymatically active on the cross-linkable protein polymer;
- and
- electrospinning the LEM to form the nanofiber comprising said cross-linkable protein polymer and said transglutaminase.
A method for producing a nanofiber, the method comprising:
- combining a first solution comprising a cross-linkable protein polymer and a second solution comprising a transglutaminase to produce a liquid electrospinning mixture (LEM) characterized by an environment that is unsuitable for the transglutaminase to be enzymatically active on the cross-linkable protein polymer;
- and
- electrospinning the LEM to form a nanofiber comprising the transglutaminase and the cross-linkable protein polymer.
A nanofiber produced by a method comprising:
- combining a first solution comprising a cross-linkable protein polymer and a second solution comprising a transglutaminase to produce a liquid electrospinning mixture (LEM), wherein the LEM is characterized by an environment that is unsuitable for said transglutaminase to be enzymatically active on said cross-linkable protein polymer;
- and
- electrospinning the LEM to form the nanofiber comprising said cross-linkable protein polymer and said transglutaminase,
- wherein said cross-linkable protein polymer comprises or consists of gelatin.
Dependencies are inferred from the claim text.