Methods for preparing pantoic acid, pantothenic acid and panthenol as well as salts thereof
AssigneeMint Biotechnologies Co., Ltd.
InventorsKechun Zhang, Jilong Wang
Life of this patent
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Abstract
Pantoic acid is obtained by fermenting substrate 2-hydroxy-3,3-dimethyl-4-aldehydobutyric acid by using bacteria or yeast. A microorganism is selected from bacteria or fungi. The microorganism is selected from wild or genetically engineered Escherichia coli, Bacillus, Corynebacterium, yeast or Streptomyces. Pantothenic acid is obtained by chemically reacting the pantoic acid obtained by the method described above with β-alanine. Panthenol is obtained by chemically reacting the pantoic acid obtained by the method described above with β-alaninol.
Claims8
A method for preparing pantoic acid or pantothenic acid or panthenol, or salts thereof, comprising a step of fermenting a substrate by a microorganism in a fermentation broth to form pantoic acid, wherein the substrate comprises 2-hydroxy-3,3-dimethyl-4-oxobutanoic acid, and the microorganism is recombinant Escherichia coli containing an exogenous gene expressing a reductase, wherein the reductase is YihU.
Dependencies are inferred from the claim text.