Synthesis and structure of high potency RNA therapeutics
AssigneeArcturus Therapeutics, Inc.
InventorsPattraranee Limphong, Carlos G. Perez-Garcia, Kiyoshi Tachikawa, Padmanabh Chivukula, Arisa Cale, Angel I-Jou Leu, Jared Davis
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Abstract
This invention provides expressible polynucleotides, which can express a target protein or polypeptide. Synthetic mRNA constructs for producing a protein or polypeptide can contain one or more 5′ UTRs, where a 5′ UTR may be expressed by a gene of a plant. In some embodiments, a 5′ UTR may be expressed by a gene of a member of Arabidopsis genus. The synthetic mRNA constructs can be used as pharmaceutical agents for expressing a target protein or polypeptide in vivo.
Claims18
A synthetic mammalian mRNA expression construct for producing a protein or polypeptide, the synthetic mammalian mRNA expression construct comprising a 5′ UTR, wherein the 5′ UTR consists of the sequence of SEQ ID NO:31.
Dependencies are inferred from the claim text.