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US 12,509,673 B2Granted
L-threonine dehydratase variant and method of producing l-isoleucine using the same
AssigneeCj Cheiljedang Corporation
InventorsKyungrim Kim, Imsang Lee, Heeyeong Kim, Kwang Woo Lee
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Abstract
An L-threonine dehydratase variant is provided that is capable of producing increased yields of the amino acid L-isoleucine when expressed in host organisms and methods of producing increased yields of L-isoleucine using the same.
Claims17
An L-threonine dehydratase variant in which an amino acid corresponding to the 381st position of an amino acid sequence of SEQ ID NO:
- 1 is substituted with a different amino acid,
- wherein the L-threonine dehydratase variant comprises a sequence having at least 96% identity with the amino acid sequence of SEQ ID NO:1, and
- wherein the different amino acid is selected from the group consisting of:
- alanine, serine, proline, glutamine, valine, isoleucine, and glycine.
1 more element
Dependencies are inferred from the claim text.